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We're so excited to try Josh Rosebrook's latest innovation, the Ultra Peptide Cream. A peptide-packed facial serum revolutionised as a weightless velvet concentrate. All you need to know...


Peptides are short chains of amino acids (the building blocks of proteins) and are cellular communicators. Naturally occurring peptides exist in the deeper layers of the skin, playing an essential role in regulating the skin's structural integrity. The peptides used in cosmetics are either isolated bioactive peptides that have to be synthetically produced, or they occur naturally as polypeptides, a component of a plant-based substance. Depending on the cost, desired potency and performance speed of a formula, formulators may choose just isolated bioactive peptides, groupings of polypeptides, or a combination of both. Josh Rosebrook's new Ultra Peptide Cream has a combination of both (of course!) to achieve access to a full spectrum of benefits. Peptides can have strings of up to fifty amino acids, and you can easily decipher how many amino acids are in a peptide by looking at the Latin prefix, di-, hexa-, tetra-, etc. For example, “tripeptide” stands for three amino acids respectively. Depending on the number of amino acids in a peptide, there are two subgroups. Isolated bioactive peptides typically have anywhere from two to ten amino acids, known as oligopeptides. In contrast, polypeptide chains are technically complex proteins made up of more than fifty amino acids - often they work synergistically with antioxidants and other phytonutrient co-factors.


• Improving skin softness 
• Improving tone and texture
• Increasing the feeling of plump, hydrated skin
• Supporting healthy, glowing skin

Between the two subgroups, there are four categories of peptides organized by their chemical behavior - neurotransmitter inhibitors peptides, enzyme inhibitors peptides, signaling peptides, and carrier peptides. Scientists recognize the fifth group of peptides known as antimicrobial peptides (AMPs), but they are mostly researched for medical applications. The main three peptide groups used in cosmetics are:

1. Signal Peptides - stimulate matrix-producing proteins and collagen synthesis. 2. Carrier Peptides - act as transport mediators while delivering essential trace elements for wound healing and enzymatic processes.
3. Neurotransmitter Peptides Inhibitors - inhibit the release of acetylcholine at the neuromuscular junction (this is where peptides get a “botox-like” reputation from).

While the use of peptides in cosmetics is on the rise globally, one of the biggest formulation challenges in working with peptides is their delivery to the skin. Getting peptides into the stratum corneum (outermost layer of the skin) alone is a feat, which is why our formulation approach is research-driven to problem-solve with chemistry and deliver results.

Josh Rosebrook's Ultra Peptide Creamstrongly focuses on skin penetration enhancers (the scientific term lipid conjugation) to allow the peptides to work with the skin. Josh Rosebrook uses the term “biomimetic” due to introducing ingredients naturally found in the skin that can become depleted over time. The act of effectively boosting ingredient levels (mimicking) activates innate skin functions such as repairing and renewing. Isn’t chemistry fun?


Palmitoyl Tripeptide-1: Signaling peptide with three amino acids. Attached to a palmitic (fatty) acid to increase solubility and skin penetration. The three specific amino acids of this peptide are considered a type 1 collagen fragment, which essentially tricks the skin into thinking that collagen has degraded and signals it to produce more. When paired with Palmitoyl Tetrapeptide-7, clinical research has shown a significant reduction in the appearance of wrinkles (both surface area and density. It’s also a peptide best suited for sensitive skin.

Palmitoyl Tetrapeptide-7: Signaling peptide with four amino acids. Attached to a palmitic (fatty) acid to increase solubility and skin penetration. Through a series of chemical signaling, the beneficial outcome for the skin is less inflammation and reduction of structural loss. When paired with Palmitoyl Tripeptide-1, clinical research has shown a significant reduction in the appearance of wrinkles (both surface area and density). It’s also a peptide best suited for sensitive skin.

Hexapeptide-11: Signaling peptide with six amino acids. Protect fibroblasts against oxidative stress and improves skin elasticity.

Polypeptides from pea extract and quinoa seed extract: Cysteine-rich hydrolyzed proteins that support skin rejuvenation and promotion of skin smoothness, along with delivering nutrient co-factors to work synergistically with protective antioxidants. Fun fact: Peptide scientists in Ireland used artificial intelligence in 2020 to isolate a specific peptide from pea extract that demonstrated effective “anti-aging” properties, including anti-wrinkle and collagen stimulatory potential.

What can peptides be combined with?
Another fantastic note about the biomimetic peptides found in Josh Rosebrook's Ultra Peptide Cream is the compatibility factor with other ingredients and products. You can pair Ultra Peptide Cream with practically any other product, and over time it will help improve your skin's overall appearance and strengthen skin health.

The serum is structured as a concentrated feather-light cream emulsion for rapid absorption while forming a thin barrier for other ingredients like ceramides, niacinamide, bio-fermentations, and fatty acids to take their hard-working time with surface rejuvenation and barrier repair.


You can’t go wrong by getting creative with the Ultra Peptide Cream! Along with the Hydrating Accelerator and C Complex Serum, it’s one of Josh Rosebrook's most universal products, efficacious for all skin types and conditions.

Morning and evening, it should be applied after using serums and oils, before moisturizing with a cream or balm. Note that for skin on the oiler side, or for people who prefer lightweight moisturizers, Ultra Peptide could be the perfect last-step product at night.

Shop Josh Rosebrook's stunning new Ultra Peptide Cream here.

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